Publication by Cecilia Bottecchia in Angewandte Chemie

14. 9. 2017 | Susan

Het artikel van Mw. Cecilia Bottecchia, MSc, van de groep van  Associate Prof. Dr. Timothy Noël van de Micro Flow Chemistry & Process Technology van de TU/e is geaccepteerd in het blad Angewandte Chemie:

Visible-Light-Mediated Selective Arylation of Cysteine in Batch and Flow
Bottecchia, C.; Rubens, M.; Gunnoo, S.; Hessel, H.; Madder, A.; Noël, T. Visible Light-Mediated Selective Arylation of Cysteine in Batch and Flow Angewandte Chemie International Edition 2017, DOI: 10.1002/anie.201706700.

A mild visible light-mediated strategy for cysteine arylation is presented. The method relies on the use of Eosin Y as a metal-free photocatalyst and aryldiazonium salts as arylating agents. The reaction can be significantly accelerated in a microflow reactor, whilst allowing the in situ formation of the required diazonium salts. The batch and flow protocol described herein can be applied to obtain a broad series of arylated cysteine derivatives and arylated cysteine-containing dipeptides. Moreover, the method was applied to the chemoselective arylation of a model peptide in biocompatible reaction conditions (room temperature, PBS buffer) within a short reaction time.