A Modular Flow Design for the meta-Selective C−H Arylation of Anilines

12. 6. 2017 | Susan

Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flowmodules(i.e., diaryliodonium salt synthesis,meta-selective C-Harylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines.With atotal residence time of 1hour,the desired product could be obtained in high yield and excellent purity without the need for column chromatography,and the residual copper content meets the standards for parenterally administered pharmaceutical substances.